D-Arbutin

D-Arbutin yog dab tsi?

D-Arbutinyog ib qho zoo heev tyrosinase inhibitor, uas muaj kev cuam tshuam tseem ceeb ntawm kev tsim melanin hauv daim tawv nqaij. Hauv kev kuaj tawv nqaij tsiaj, deoxyarbutin tuaj yeem cuam tshuam qhov kev txiav txim ntawm tyrosinase hauv cov ntaub so ntswg ntawm daim tawv nqaij, ua kom tawv nqaij sai thiab zoo, thiab cov nyhuv tseem tuaj yeem tswj tau ze li ntawm 8 lub lis piam thaum cov khoom raug tso tseg. Lub sij hawm, nws lub zog yog 10 npaug ntawm hydroquinone thiab 350 npaug ntawm cov arbutin.

COA ntawm D-Arbutin:

D-Arbutin ua li cas?

(1) Muab 220 mL ntawm methanol rau hauv 500 mL peb-caj dab, maj mam ntxiv 100 g ntawm sodium methoxide tov, do kom txog thaum yaj, kub rau 64.5 degree, ntxiv 55 g ntawm hydroquinone, do rau 10 min, thiab dropwise ntxiv 53.8. g ntawm hydroquinone hauv 90 min g benzyl chloride. Tom qab poob lawm, cov tshuaj tiv thaiv kub tau khaws cia ntawm 64.5 degree, thiab cov tshuaj tiv thaiv txuas ntxiv mus txog thaum tsis muaj cov khoom siv raw.

Cov tshuaj tiv thaiv tau raug xa mus rau ib lub caj dab caj dab, cov kuab tshuaj tau evaporated nyob rau hauv lub siab txo, txias rau chav tsev kub, thiab acidified los ntawm kev ntxiv 5 0 mL ntawm 6.0 molL ' hydrochloric acid. Nyob rau lub sijhawm no, cov khoom loj heev tau ua los nag, kev nqus pom tau ua tiav, thiab lub ncuav mog qab zib lim tau hloov mus rau hauv 250 mL ntawm 1.5 molL 'ntawm hydrochloric acid. Aqueous sodium hydroxide tov, stirred rau 30 min, lim nrog suction, xa cov lim mus rau ib tug 500 mL hwj, acidified los ntawm dropwise ntxiv ntawm 45 mL ntawm concentrated hydrochloric acid, suction lim lub precipitated khoom, ntxuav lub lim ncuav mog qab zib nrog dej kom txog thaum nruab nrab, Thiab tom qab ntawd hloov cov khoom mus rau hauv cov tshuaj uas muaj 100 Nyob rau hauv ib lub khob peb-caj dab uas muaj mL methanol, 2 g ntawm activated carbon tau ntxiv, refluxed rau 16 h, nqus lim, thiab cov kuab tshuaj yog evaporated nyob rau hauv txo lub siab kom tau 78.3 g ntawm cov khoom. cov khoom lag luam nrog cov txiaj ntsig ntawm 75.2%.

(2) Muab 350 mL ntawm dichloromethane thiab 37.5 g ntawm p-benzyloxyphenol rau hauv 500 mL peb-caj dab, thiab ntxiv 3.29 g ntawm pyridine p-toluenesulfonate tom qab 30 min, do rau 10 min, thiab dropwise ntxiv 50 mL ntawm 3, 4-dihydrogen Lub pyran. cov tshuaj dichloromethane tau tshwm sim ntawm 30 degree rau 5 h, thiab cov tshuaj tiv thaiv tau ua tiav los ntawm TLC tsom xam.

125 mL (2.0 mol'L') aqueous sodium hydroxide tov yog siv los ntxuav cov tshuaj tiv thaiv cov khoom hauv cov kauj ruam dhau los, 20 g ntawm anhydrous sodium sulfate tau ntxiv rau qhuav, qhov hnyav tau tig-qhuav hauv qab txo qis. Lub siab mus rau cov khoom oily, thiab cov khoom oily tau nchuav rau hauv 120 mL ntawm n-hexane, o Tom qab nplawm ntawm qib rau 1 h, cov khoom tau muab cais tawm los ntawm kev pom, thiab 42.5 g ntawm cov khoom tau txais tom qab ziab, nrog kev tawm los. ntawm 80%.

(3) Muab 175 mL ntawm ethyl acetate thiab 42.5 g ntawm 2-[(4-benzyloxy)phenoxy]tetrahydropyran rau hauv 500 mL peb-caj dab, thiab do rau 10 feeb. Tom qab tag nrho cov khib nyiab tau yaj, 4 g ntawm sodium carbonate thiab 5 g ntawm palladium ntawm carbon tau ntxiv, hydrogen tau qhia, thiab qhov sib tov yog nplawm ntawm 30 degree rau 24 teev. Hauv kev nqus pom, cov filtrate tau evaporated nyob rau hauv qhov txo qis rau cov khoom oily, 37.5 mL ntawm methanol thiab 50 mL dej ntxiv, thiab nplawm ntawm 10 degree rau 1 h, thiab cov khoom loj yog precipitated, lim, thiab qhuav. kom tau txais cov khoom lag luam 4-[(2-tetrahydropyran)oxy]phenol 23 g.

Vim li cas D-Arbutin loj hlob hauv kev muaj koob npe?

D-Arbutinyog ib tug ncaj elastic anti-melanin muaj. Nws tuaj yeem siv tau ntev heev thaum tus neeg siv xav ua kom cov tawv nqaij zoo dua, thiab kev siv deoxyarbutin txo qis thaum tus neeg siv yuav tsum tau raug tshav ntuj ntev. , los kho cov haujlwm tseem ceeb ntawm melanin, nws tuaj yeem tiv thaiv thiab tiv thaiv peb lub cev kev noj qab haus huv, uas yog qhov chaw deoxyarbutin tau nyiam ntau yam.

Yog koj txaus siab rauD Arbutin hmoovthiab xav paub qhov twgmuas arbutin? Tom qab ntawd thov hu rau peb ncaj qha los ntawm nplooj ntawv no lossis yuav arbutin ncaj qha los ntawmmedical@ysgcn.com

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